P001 · F · 43 yrs · BMI 27.4

Patient Case Intake

Select a canonical demo case to load multimodal input data: genomic SNPs, bloodwork analytes, or benchtop biosensor epochs.

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Case A — Oxidative Stress
P001 · Female · 43 yrs · BMI 27.4
Oxidative stress / inflammation dominant phenotype
10 SNPs IL6 · CRP · SOD2 CYBA · TNF · GPX1
Data loaded — ACTIVE
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Case B — Methylation/Detox
P002 · Male · 38 yrs · BMI 24.9
Methylation / detox / nutrient handling dominant
28 Analytes Hcy · B12 · Folate SAM · SAH · MMA
Data loaded — ACTIVE
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Case C — Stress/Autonomic
P003 · Female · 36 yrs · BMI 22.1
Stress-autonomic / recovery dominant phenotype
30 Epochs PPG · HRV · GSR 23 Channels
Data loaded — ACTIVE

Dataset Index

CHL DNA KEY® INTRINSICA® · DEMO · Three structured cases covering the CHL EPI/ECP computational pipeline · June 2026
Sheets: Patients · Genomics_CaseA · Labs_CaseB · Sensors_CaseC · Predicates (8 HP + EPI/ECP) · Certificate (SHA-256 · Eq.20)

🛡 SAFETY-FREEZE condition detected — drift_metric approaching threshold. Practitioner review required before proceeding.

8 Health Predicates — Priority Ranked

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Explainability Panel

Select a predicate
Click any predicate row above to reveal the computational basis, contributing markers, and EPI/ECP scalars for that health domain.
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DNA KEY® Nutritional Intervention Protocol

MODULE A · EPI-GATED
Case A — Oxidative / Inflammation · HP2 · HP8 dominant
Genotype-Adjusted Supplement Protocol
Component Adjusted Dose Target Pathway SNP Basis
Implementation Timeline · Wk 1 → Wk 8

Patient Summary

EPI/ECP Scalars

Practitioner Actions

ECP Clinical Operations

The nine-phase closed-loop precision health workflow. Executed on a continuous quarterly cadence for every enrolled patient — practitioner-supervised, HITL-governed, 48-hour APPROVE / MODIFY / REJECT.

Closed-Loop HITL-Governed 21 CFR Part 11 SHA-256 Audit
1
Patient Enrollment
Licensed practitioner enrolls patient via ECP clinical portal. Licensure verification activates the patient's unique computational instance on the INTRINSICA® remote server.
Clinical portal · licensure verified
2
Four-Stream Data Acquisition
All four heterogeneous streams activate simultaneously: (A) Genomic 6-SNP CLIA genotyping, (B) Baseline + quarterly biomarker panels, (C) Continuous wearable streaming, (D) Patient-reported diet / sleep / stress / adherence.
Genomic · Biomarker · Wearable · PRO
3
WKD Semantic Integration
Data ingested into the Wisdom-Knowledge-Data architecture with SNOMED-CT / LOINC / RxNorm ontology mapping. Data → Knowledge → Wisdom (ACFL reasoning) layers.
SNOMED-CT · LOINC · RxNorm
4
ACFL Health Assessment
ACFL engine evaluates 8 multi-domain predicates (Metabolic Stability, Stress Adaptation, Oxidative Stress Balance, Cardiovascular Resilience, Nutritional Sufficiency, Methylation Capacity, Stress Recovery, Dehydration Stability) → scored 0–10.
8 predicates · inspectable
5
EPI-Gated Attenuation
Outputs pass through a EPI-gated attenuation layer. When biological coherence is low (EPI → 0), recommendation confidence is attenuated proportionally — a safety feature with no commercial analog.
Computational System· safety-gated
6
Practitioner Review — HITL Gateway
Gain-gated recommendations presented on the practitioner dashboard requiring explicit APPROVE / MODIFY / REJECT within 48 hours. No intervention occurs without authorization — architecturally enforced.
APPROVE / MODIFY / REJECT · 48h
7
Intervention Deployment
On APPROVE / MODIFY, the genomically targeted DNA KEY® formulation deploys per Module A dosing. All events logged in the 21 CFR Part 11 audit trail with SHA-256 hash chain.
DNA KEY® · Module A dosing
8
Governed-Continuous Calibration
Each APPROVE / MODIFY / REJECT + rationale is a Goverance-class operation — a Lipschitz-bounded parametric refinement (Lmax ≤ 0.1 per unit time). The system learns from practitioner expertise within certified stability bounds.
Lipschitz-bounded · L ≤ 0.1
9
Longitudinal Monitoring & Outcome Validation
Post-intervention EPI trajectory and quarterly biomarker trends validate efficacy. The cycle repeats each interval, generating a continuously improving patient model and an RWE-grade evidence trail.
EPI trajectory · RWE

ECP Billing Model

INTRINSICA EDIM · ROS dual-path Medicare reimbursement model. ECP creates no new codes — it makes existing, medically necessary, documented, separately reportable work defensible. Rates: CY2026 Medicare PFS, national-average, non-facility.

⚠ Not legal, coding, or billing advice. Verify payer policy, MAC/LCD & frequency before submission.
PATH 1 · Near-Future
EDIM · ROS — 3rd-Party Wearables
Apple Watch / Oura / Garmin + clinical labs via FHIR. Consumer wearables generally don't qualify as FDA RPM devices, so the model leans on RTM, 99091, EM, care-management & counseling.
$1,594annual / patient
Revenue PMPM$132.85
Panel (500 pts)$797,100
RPM codesConditional
PATH 2 · Future
EDIM · ROS — INTRINSICA Biophotonic Wristband
Purpose-built medical-grade device (HRV, bioimpedance phase angle, optical resonator) unlocks the full RPM suite, materially raising per-patient capture.
$1,775annual / patient
Revenue PMPM$147.95
Panel (500 pts)$887,706
Δ vs Path 1+$181 / +11.4%

Core Code Families

CY2026 PFS
CodeFamilyService2026 RatePath
99214EM OfficeEst. pt, moderate MDM — primary ECP review code$128.331 · 2
99215EM OfficeEst. pt, high complexity$182.081 · 2
G2211EM Add-onLongitudinal complexity add-on (Medicare)$16.501 · 2
G0439PreventiveSubsequ
9:41 INTRINSICA® ●●●
👤
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DCI ACTIVE
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Your Health Areas
Your Supplement Plan
Practitioner-reviewed
Your 8-Week Plan
Coming Up
🏠 Home
📈 Progress
📋 Plan
👤 Profile
RESEARCH USE ONLY  ·  NOT FOR CLINICAL USE

👁 Patient Lens Context

What the patient sees vs. doesn't
✅ Patient sees: EPI zone label (Stable / Transition / Elevated), 8 friendly predicate names with progress bars, supplement plan with doses, 8-week timeline, retest reminder
🚫 Hidden from patient: Raw EPI scalar values, SNP IDs, lab values, Certificates, SAFETY-FREEZE status, drift metrics, Lipschitz bounds
🔒 Privacy layer: No identifiable genomic data rendered client-side. Patient ID shown, not data source. All clinical interpretation remains practitioner-gated.
⚖️ Regulatory posture: Patient view is wellness-framed. All RESEARCH USE ONLY labels. No diagnostic language presented to patient.

🤝 HITL Interaction Preview

MVP2 — Not Active

Human-in-the-loop patient actions will be enabled in MVP2. Shown here for investor/practitioner context only.

📚 Education Content

Patient-facing library

Plain-language explanations for each predicate and supplement. Practitioner-curated. Research-compliant.

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What is Oxidative Stress?
2 min read · Plain language
Ready
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Cellular Hydration & Why It Matters
3 min read · Plain language
Ready
💊
Your Supplement Guide
Personalized · Case-linked
Ready
📈
Understanding Your Progress Timeline
Video + text · 5 min
MVP2
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How Your Profile Was Built
Interactive explainer · MVP2
MVP2
RESEARCH USE ONLY  ·  NOT FOR CLINICAL USE  ·  CHL R10 GOVERNANCE